Spectroscopic Imaging Laboratory

The Spectroscopic Imaging Laboratory at University of Kentucky is dedicated to develop novel optical methods to advance translational cancer research. The central focus of the group’s research is to develop optical imaging tools for biomedical applications related to tumor metabolism, hypoxia and angiogenesis. Current projects include the following topics.

  • Development of optical platforms including spectroscopy and microscopy
  • Computer simulation of light transport in tissue
  • Cancer therapies prediction and evaluation
  • Cancer metabolism pathway reprogramming

Our lab has openings for students.  For more details, see Openings


Our work on ratio-metric technique has been published at Journal of Biomedical Optics

In this report, we developed a ratio-metric technique for rapid quantification of key metabolic probes from fluorescence spectra measured on a tissue-mimicking turbid medium. The proposed method will potentially facilitate real-time monitoring of key metabolic parameters of tumor models in vivo using optical spectroscopy/microscopy, which will significantly advance translational cancer research. Congratulations to our postdoc Owen, who is the first author of this work !  (http://dx.doi.org/10.1117/1.JBO.26.4.045001)

Our Group Receives Igniting Research Collaborations Pilot Grant

Our project  titled “Optical imaging of radiation-induced metabolic changes in human breast cancer organotypic tumor slices to predict radiotherapy response." has been selected for receiving a pilot grant through UK’s “Igniting Research Collaborations (IRC)” program. This IRC seed award will support our efforts to gather crucial preliminary data for the successful application of larger grants to the National Institutes of Health and foundations. (https://www.engr.uky.edu/news/2020/12/zhu-receives-igniting-research-col...)


Our first peer reviewed journal article has been published !

Our first journal article has been published in Biomedical Optics Express. In this report, we identifed optimal fiber probe design for logitudinal monitoring of tumor metabolism and vasculature. Congratulations to the team !  (https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-11-11-6311&id=441079)