The Spectroscopic Imaging Laboratory at University of Kentucky is dedicated to develop novel optical methods to advance translational cancer research. The central focus of the group’s research is to develop optical imaging tools for biomedical applications related to tumor metabolism, hypoxia and angiogenesis. Current projects include the following topics.
Our lab has openings for students. For more details, see Openings.
April 23, 2021
In this report, we developed a ratio-metric technique for rapid quantification of key metabolic probes from fluorescence spectra measured on a tissue-mimicking turbid medium. The proposed method will potentially facilitate real-time monitoring of key metabolic parameters of tumor models in vivo using optical spectroscopy/microscopy, which will significantly advance translational cancer research. Congratulations to our postdoc Owen, who is the first author of this work ! (http://dx.doi.org/10.1117/1.JBO.26.4.045001)
December 2, 2020
Our project titled “Optical imaging of radiation-induced metabolic changes in human breast cancer organotypic tumor slices to predict radiotherapy response." has been selected for receiving a pilot grant through UK’s “Igniting Research Collaborations (IRC)” program. This IRC seed award will support our efforts to gather crucial preliminary data for the successful application of larger grants to the National Institutes of Health and foundations. (https://www.engr.uky.edu/news/2020/12/zhu-receives-igniting-research-col...)
October 19, 2020
Our first journal article has been published in Biomedical Optics Express. In this report, we identifed optimal fiber probe design for logitudinal monitoring of tumor metabolism and vasculature. Congratulations to the team ! (https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-11-11-6311&id=441079)